PROTAC: mechanism of action
➣ PROTAC (Proteolysis-targeting chimera) utilizes the natural protein degradation system "ubiquitin protease system" within cells to achieve targeted protein degradation.
➣ The bifunctional molecule PROTAC plays a "proximity-inducing" role, binding to target proteins and activated E3 ligases to form a ternary complex with a certain spatial configuration and stability.
➣ The ubiquitination label on E3 ligase is transferred to the target protein.
➣ The ubiquitinated target protein is recognized and degraded by the proteasome system, and the released PROTAC molecules can participate in the next round of protein degradation.
PROTAC: mechanism of action
