Bradykinin receptor antagonist: mechanism of action

➣ In different cells constituting the tumor microenvironment, the activation of bradykinin (BK) receptor will lead to a series of actions, such as the release of MMPs, growth factors and inflammatory mediators, thus promoting tumor growth, angiogenesis, invasion and cancer metastasis.
➣ The expression level of B1 receptor is very low in normal tissues, but it is enhanced in various cancers. B2 receptors are widely present in human tissues and have been detected in various cancers, including head and neck squamous cell carcinoma, osteosarcoma, endometrial cancer, prostate cancer, kidney cancer, cervical cancer, lung cancer, and gastric cancer.
➣ The PL-AC series of compounds may significantly inhibit tumor cell growth, invasion, and metastasis by acting on the B1/2 receptor.


The relationship between BK and tumor growth, invasion, and metastasis